SEE THE UNSEEN® WITH FUGENE®
Best in Class Transfection Reagents
For over 30 years, FuGENE® has been working to better understand how to gently transfect genetic material into cells. We now provide unique reagents that allow our customers to easily obtain high RNA and DNA transfection rates without disturbing normal cell function. So come and experience the gentle magic of FuGENE and let us help you “see the unseen”.
SEE THE UNSEEN® WITH FUGENE®
Our Transfection Reagents
DNA Transfection Reagent
FuGENE® 4K is our most advanced, 100% synthetic, multi-component transfection reagent designed for the delivery of plasmids for high yield production of proteins and viruses.
Features
- Optimized for high yield protein expression or high titer viral production
- Outperforms Lipofectamine™ 3000 in most cell types
- Enhanced stability and storage at room temperature
DNA Transfection Reagent
FuGENE® HD is a 100% synthetic, transfection reagent designed for the delivery of DNA into more challenging eukaryotic cells proven in over 1000 different cell types
Features
- Our best-selling reagent to date
- The go-to reagent when using macrophages
- Superior efficiency with minimal-to-no toxicity
- Quick protocol with easy optimization steps
DNA Transfection Reagent
Our original transfection reagent with over 25 years on the market. FuGENE® 6 is our most gentle reagents and allows for efficient delivery of DNA into a broad range of cell types.
Features
- Our best reagent if reagent toxicity is a concern
- Quick protocol with easy optimization steps
- Legacy product with over 25 years on the market

RNA Transfection Reagent
FuGENE® RX is an RNA transfection reagent that efficiently delivers all types of RNA gently into a wide variety of cell types. RX is also a great choice for running CRISPR experiments.
Features
- Performs well with all types of RNA and most cell types
- Shows a superior % of transfected cells with high and rapid protein yields
- Outperforms MessengerMax®
RNA Transfection Reagent
FuGENE® SI is a 100% synthetic, multi-component transfection reagent designed for the delivery of small inhibitory RNA molecules into eukaryotic cells for efficient gene silencing.
Features
- Gentle siRNA transfection reagent with outstanding efficiency
- Utilize lower amounts of transfection reagent and siRNA
- Simple, easy-to-use protocol and optimization
Testimonials
What Our Customers Are Saying...






Features
Why Our Reagents?
Proven
For over 25 years researchers have been using FuGENE® products for gentle and reliable transfection across countless cell lines and applications. You can always count on the consistent quality of FuGENE® transfection for your experiments.
High Expression
FuGENE® reagents are known for their high transfection efficiency across a wide range of cell types, including hard-to-transfect cells. This makes them suitable for diverse applications in genetic research and biotechnology.
Gentle on Cells
One of the key features of FuGENE® reagents is their low cytotoxicity. Unlike some other transfection methods, FuGENE® reagents are gentle on cells, minimizing the stress and damage that can lead to cell death or altered cell function.
User-Friendly
The protocol for using FuGENE® reagents is straightforward and does not require extensive optimization. This user-friendly aspect saves time and resources in laboratory settings.

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Take the Next Step in Your Research Journey Today!
Whether you’re working with DNA or RNA, trying to make proteins or viruses, you must try our Best-in-Class Reagents today as they offer ease of use, high efficiency, and extremely low levels of off-target side effects.
Can we help you?
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Contact us with any questions you may have. Please complete the form below to have a FuGENE® representative get in touch with you.

FAQs
Find Answers to Our Most Frequently Asked Questions
What reagent do you suggest for stem cell research?
FuGENE® 6, HD, and 4K have all been utilized in Stem Cell Research. If you have questions about a particular cell line, the citation database on our website is a great resource (www.fugene.com/citations-database/). Search by key attributes such as cell type, application, product line, or year of publication. If you still feel unsure, contact our technical team at contact@fugene.com.
How is FuGENE® 4K chemically different from Lipofectamine® 3000?
FuGENE® 4K is a multi-component blend of polymers and lipids that allows high efficiency transfection while remaining gentle. In addition, 4K is capable to producing high yields of Lenti Virus using most any type of HEK293 cell and multiple types of growth media.
Does Promega or Roche manufacture FuGENE® reagents?
No, only FuGENE manufactures FuGENE reagents. To better serve our customers, you can now order our products directly through this web site or through our many distributors. Regarding Roche and Promega; in 2010 Promega replaced Roche as our World Wide distributor.
What do you suggest if I am having a hard time transfecting my cells with FuGENE® Transfection Reagents?
We suggest you check our Resource page and if still having trouble contact us directly through this site. We are always here to help.