Empowering Biomedical Discovery

 

The challenge of keeping the world healthy and safe has never been greater.  FuGENE stands as a partner with the research & medical community in pushing innovative discoveries and therapeutics forward, helping to make the world a better place one cell at a time.

 

Gene Expression

Gene Expression

Regulating and measuring gene expression are important tools in biomedical research. Misregulation of gene expression causes a range of diseases. FuGENE facilitates the study of gene expression by delivering nucleic acids to inhibit or enhance protein expression in various tissues and organs.

Cellular Analysis

Cellular Analysis

Surpassing more than a trillion in the human body, cells are the fundamental building blocks of all life. FuGENE allows the efficient and non-toxic delivery of nucleic acids into cells for many biomedical applications. Understanding of key cellular processes like cell signaling, cell growth and death, cell migration, metabolism, drug resistance, oxidative stress, and cell migration are critical to understanding disease and possible therapeutics.

Virus Production

Virus Production

Lentivirus and AAV are lab engineered virus types commonly used for research, and gene & cell therapy applications. These beneficial virus particles are produced by transfecting CHO and HEK293 cell lines with FuGENE + DNA which encodes for the virus production machinery.

Protein Production

Protein Production

One of the most promising applications of transfection is the development of therapeutic proteins & antibodies to treat and cure disease. Therapeutic proteins are produced by transfecting cells with FuGENE + the desired nucleic acid which instructs the cell to manufacture the intended novel proteins.

Immunology

Immunology

Immunology is the study of the immune system, the first-in-line defense of the human body when a foreign pathogen enters. Cell mediated immune responses are essential in controlling infections and preventing tumor growth. By overcoming barriers in transfecting difficult-to-transfect cell lines, FuGENE has become an important tool for better understanding how immune cells function.

Cancer Research

Cancer Research

Cancer kills an average of 10 million people annually worldwide. It is typically caused by cellular mutations that lead to uncontrollable, abnormal cell division & tumor growth. FuGENE is an essential tool in delivering nucleic acids to cancer cell lines to help understand how & why cancer cells mutate, and what can be done to better treat patients and save lives.

Genome Editing

Genome Editing

Genome editing is a popular technique utilized in research and therapeutic applications to make permanent changes to a cell’s DNA. The development of CRISPR revolutionized the ease and accessibility of this technology. FuGENE facilitates the delivery of CRISPR encoding DNA to allow efficient, safe, and easy gene editing.

Stem Cell Research

Stem Cell Research

Stem cells can divide and differentiate to become specialized cells of different kinds like lung, pancreas, heart muscles, red blood cells, skin, and neurons. Stem cell research has the potential to cure diseases like leukemia, cardiovascular diseases, diabetes, and spinal cord injuries. High transfection efficiencies obtained by delivering nucleic acids with FuGENE are essential to stem cell reprogramming and differentiating.

Gene Silencing

Gene Silencing

Gene silencing is a popular tool for functional genomics and has been used in various therapeutic applications for the down-regulation of disease-causing genes. Gene expression can be inhibited by transfecting small non-coding RNA molecules into cells with FuGENE. Researchers will typically utilize either small interfering RNA (siRNA), micro RNA(miRNA), or short hairpin RNA (shRNA) in the process.

Epigentics

Epigentics

Epigenetics is a change in organism caused by the modification of gene expression rather than the genome itself. It helps to determine whether the genes are turned on or off. Epigenetic modifications can remain when cells divide or they can be modified due to various environmental factors. Transfection of nucleic acids into cells with FuGENE can be used to induce various epigenetic modifications for change in protein expression.

Neurology

Neurology

Neurology is a branch of medicine that deals with disorders of the nervous system of the body. The efficient transfection of genes into neuronal cells with FuGENE and the production of transduction ready virus with FuGENE is essential for the study of a neuron’s behavior. Understanding neuronal function is key to preventing and treating neurodegenerative diseases such as Parkinson’s and ALS.

Gene & Cell Therapy

Gene & Cell Therapy

Gene & Cell Therapy holds promising treatment options for various diseases such as cancer, heart diseases, diabetes, cystic fibrosis, hemophilia, and AIDS. Transfection with FuGENE allows the engineering of these cells by providing the missing genetic material, removing unwanted genetic material, or by an increase or decrease in the genetic expression.